Description

Fmoc-Ile-n-Carboxyanhydride is a specialized, high-purity amino acid derivative used as a key building block in solid-phase peptide synthesis (SPPS). This compound matters because it enables the efficient, racemization-free incorporation of isoleucine into peptide chains under mild conditions, which is critical for producing complex peptides with high fidelity. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, peptide hormones, and biochemical tools. The product is supplied with a focus on batch-to-batch consistency to support reproducible scientific and manufacturing outcomes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated amino acid derivative for the sequential coupling of isoleucine residues.
• Pharmaceutical R&D: For the research and development of novel peptide-based therapeutics and drug candidates.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive peptides.
• Bioconjugation: In the site-specific modification of peptides and proteins for diagnostic or therapeutic purposes.
• Academic Research: For fundamental studies in biochemistry, medicinal chemistry, and chemical biology involving peptide structures.
• Production of Custom Peptides: By CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) for client-specific projects.

Basic Information

Product Name	Fmoc-Ile-n-Carboxyanhydride
CAS No.	129288-41-1
Molecular Formula	C20H19NO5
Molecular Weight	353.37 g/mol
Synonyms	Fmoc-Ile-NCA; N-(9-Fluorenylmethoxycarbonyl)-L-isoleucine N-carboxyanhydride; Fmoc-L-isoleucine NCA; (4S)-4-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-methyl-2,5-dihydro-1,3-oxazole-2,5-dione; Nα-Fmoc-L-isoleucine anhydride; Fmoc-Ile-OCO-O; Fmoc-isoleucine N-carboxy anhydride; N-Fmoc-L-isoleucine N-carboxyanhydride
EINECS	Contact for details

Quality Control

Our Fmoc-Ile-n-Carboxyanhydride is manufactured under strict quality management systems to ensure the high purity and consistency required for sensitive synthetic applications. Each batch is subjected to rigorous analytical testing, including HPLC for purity assessment and chiral analysis to confirm enantiomeric integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive (hygroscopic) nature. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and hydrolysis. For long-term stability, desiccants are recommended within the storage environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.