Description

Fmoc-Gly-n-Carboxyanhydride is a specialized N-carboxyanhydride (NCA) derivative used for the controlled synthesis of polypeptides and peptide-polymer conjugates. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the efficient, racemization-free introduction of glycine residues under Fmoc-protection strategies. It is essential for researchers and manufacturers in pharmaceutical development, bioconjugation, and advanced materials science who require high-purity, reliable reagents for constructing complex biomimetic structures.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for the controlled, stepwise elongation of peptide chains using Fmoc-chemistry protocols.
• Ring-Opening Polymerization (ROP): Serves as a high-purity initiator for the synthesis of well-defined polyglycine and polypeptide-based block copolymers.
• Bioconjugation and Drug Delivery: Used to create peptide-functionalized carriers, nanoparticles, and surfaces for targeted therapeutic applications.
• Biomaterial Fabrication: Enables the production of synthetic polypeptides for hydrogels, scaffolds, and other bioactive materials.
• Research & Development: A vital reagent in academic and industrial R&D for exploring new peptide architectures and polymer-peptide hybrids.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening of bioactive peptide sequences.

Basic Information

Product Name	Fmoc-Gly-n-Carboxyanhydride
CAS No.	129288-40-0
Molecular Formula	C₁₉H₁₅NO₆
Molecular Weight	353.33 g/mol
Synonyms	Fmoc-Glycine N-Carboxyanhydride; Fmoc-Gly-NCA; N-(9-Fluorenylmethoxycarbonyl)glycine N-Carboxyanhydride; 2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]acetic acid anhydride; 5-Oxo-4,6-dioxa-1-azaspiro[2.4]heptane-1-carboxylic acid, 1-(9H-fluoren-9-ylmethyl) ester; Fmoc-Glycine anhydride; N-Fmoc-glycine NCA
EINECS	Contact for details

Quality Control

Our Fmoc-Gly-n-Carboxyanhydride is manufactured under controlled conditions to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes rigorous analytical testing, including HPLC for assay and purity, NMR for structural confirmation, and chiral analysis to ensure optical integrity. Certificates of Analysis (COA) documenting full specifications are available upon request, supporting compliance in GMP-oriented research and production environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.