Description

Ethyl (1R,3R)-1-{[(tert-Butoxy)Carbonyl]Amino}-3-Hydroxycyclobutane-1-Carboxylate is a high-purity, chiral cyclobutane derivative serving as a critical building block in advanced organic synthesis. This compound matters because it provides a protected amino acid scaffold essential for constructing complex, biologically active molecules with precise stereochemistry. Pharmaceutical R&D and fine chemical manufacturers need it for developing novel therapeutic candidates, particularly in peptide mimetics and small-molecule drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetics Research: Used to construct constrained peptide analogs and macrocycles to improve metabolic stability and binding affinity.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to introduce the cyclobutane motif.
• Chemical Biology Probes: Incorporation into molecular probes to study protein-protein interactions and enzyme mechanisms.
• Advanced Material Precursors: Potential use in creating specialized monomers for polymers with unique structural properties.

Basic Information

Product Name	Ethyl (1R,3R)-1-{[(tert-Butoxy)Carbonyl]Amino}-3-Hydroxycyclobutane-1-Carboxylate
CAS No.	129288-14-8
Molecular Formula	C13H23NO5
Molecular Weight	273.33 g/mol
Synonyms	(1R,3R)-1-[(tert-Butoxycarbonyl)amino]-3-hydroxycyclobutane-1-carboxylic acid ethyl ester; Ethyl (1R,3R)-1-[(Boc)amino]-3-hydroxycyclobutane-1-carboxylate; Boc-(1R,3R)-AHCB-OEt; (1R,3R)-1-(Boc-amino)-3-hydroxycyclobutanecarboxylic acid ethyl ester; Ethyl 1-[(tert-butoxycarbonyl)amino]-3-hydroxycyclobutane-1-carboxylate (1R,3R)-isomer; Boc-AHCB(1R,3R)-OEt; Cyclobutane derivative, Boc-protected amino acid ester
EINECS	Contact for details

Quality Control

Our Ethyl (1R,3R)-1-{[(tert-Butoxy)Carbonyl]Amino}-3-Hydroxycyclobutane-1-Carboxylate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including chiral HPLC and NMR, to ensure high chemical and enantiomeric purity suitable for sensitive pharmaceutical applications. Certificates of Analysis (COA) with full specification data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.