Description

(+)-α-Benidipine Hydrochloride CAS NO 129262-08-4 is a high-purity, enantiomerically pure dihydropyridine calcium channel blocker. This compound is of significant interest in pharmaceutical research and development due to its potent and long-lasting antihypertensive and antianginal effects. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in cardiovascular drug discovery, pharmacology studies, and the development of novel therapeutic formulations.

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API): Core component in the research and production of antihypertensive and antianginal medications.
• Biomedical Research: Used as a reference standard and tool compound in pharmacological studies to investigate L-type and T-type calcium channel blockade.
• Preclinical Development: Essential for pharmacokinetic, pharmacodynamic, and toxicology studies during drug candidate screening.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.
• Formulation Development: Used in the development of various dosage forms, including tablets and capsules.
• Chemical Synthesis Intermediate: Employed in the synthesis of more complex molecules or derivatives for structure-activity relationship (SAR) studies.

Basic Information

Product Name	(+)-α-Benidipine Hydrochloride
CAS No.	129262-08-4
Molecular Formula	C28H31N3O6 • HCl
Molecular Weight	542.02 g/mol
Synonyms	(+)-Benidipine Hydrochloride; (R)-(+)-Benidipine Hydrochloride; Benidipine HCl; KW-3049; Coniel; (R)-(+)-2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[1-(diphenylmethyl)-3-azetidinyl] 5-methyl ester hydrochloride; (3R)-1-(Diphenylmethyl)-3-[(4R)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate]azetidine hydrochloride
EINECS	Contact for details

Quality Control

Our (+)-α-Benidipine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets stringent specifications for pharmaceutical research. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with cGMP and ICH guidelines for API development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.