Description

5-9-Leuprolide is a synthetic nonapeptide analog of naturally occurring gonadotropin-releasing hormone (GnRH). This compound is a critical intermediate in the synthesis of Leuprolide Acetate, a widely used active pharmaceutical ingredient (API) for treating hormone-sensitive conditions. It is essential for pharmaceutical manufacturers and research institutions developing advanced hormonal therapies and controlled-release formulations. The material is supplied as a high-purity intermediate to ensure the integrity and efficacy of the final drug product.

Application

• Pharmaceutical Intermediate: Primary use as a key building block in the synthesis of the active pharmaceutical ingredient Leuprolide Acetate.
• Oncology Therapeutics: Used in the production of drugs for treating prostate cancer, endometriosis, and central precocious puberty.
• Hormone Research: Serves as a reference standard and starting material in biochemical research involving GnRH receptor studies.
• Controlled-Release Formulations: Integral to developing long-acting depot injections and implantable drug delivery systems.
• Process Development & Scale-Up: Employed in process chemistry for optimizing synthetic routes and manufacturing processes under cGMP.
• Analytical Standard: Used as a high-purity standard for quality control testing, method validation, and regulatory submissions.

Basic Information

Item	Detail
Product Name	5-9-Leuprolide
CAS No.	129244-90-2
Molecular Formula	C₆₀H₈₆N₁₆O₁₃
Molecular Weight	1247.44 g/mol
Synonyms	Leuprolide (5-9); Leuprorelin (5-9) fragment; pGlu-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt; GnRH Agonist Fragment (5-9); LHRH Agonist Peptide (5-9); Leuprolide Intermediate; 5-9 Peptide Sequence of Leuprolide; Des-Gly¹⁰, AzGly¹¹-NH₂-Leuprolide (5-9)
EINECS	Contact for details

Quality Control

Our 5-9-Leuprolide is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and assay, mass spectrometry for identity confirmation, and tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with relevant pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions or lower temperatures.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0% (Total Peptide Content)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.