Description

3-Aminomethyl-5-(4-Chlorophenyl)-Tetrahydrofuran-2-One is a high-purity, functionalized lactone building block of significant interest in advanced organic synthesis. Its unique structure, featuring both an aminomethyl group and a chlorophenyl moiety, makes it a versatile intermediate for constructing complex molecular architectures. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Serves as a precursor in the manufacture of advanced pesticides and herbicides, leveraging the chlorophenyl group for bioactivity.
• Ligand and Catalyst Development: Used in organometallic chemistry to create novel ligands for asymmetric catalysis and metal complexation.
• Peptidomimetic Research: The lactone and amine functionalities make it suitable for constructing constrained peptide analogs and protease inhibitors.
• Material Science Monomer: Potential use as a specialty monomer for synthesizing polymers with specific functional groups for advanced material applications.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and tags for studying biological systems and pathways.

Basic Information

Product Name	3-Aminomethyl-5-(4-Chlorophenyl)-Tetrahydrofuran-2-One
CAS No.	129238-75-1
Molecular Formula	C12H14ClNO2
Molecular Weight	239.70 g/mol
Synonyms	5-(4-Chlorophenyl)-3-(aminomethyl)oxolan-2-one; 3-(Aminomethyl)-5-(4-chlorophenyl)dihydrofuran-2(3H)-one; 5-(p-Chlorophenyl)-3-(aminomethyl)tetrahydro-2-furanone; 3-Aminomethyl-5-(4-chlorophenyl)-2-oxotetrahydrofuran; 3-(Aminomethyl)-5-(4-chlorophenyl)-2-tetrahydrofuranone; 129238-75-1; Tetrahydro-2-furanone, 3-(aminomethyl)-5-(4-chlorophenyl)-
EINECS	Contact for details

Quality Control

Our 3-Aminomethyl-5-(4-Chlorophenyl)-Tetrahydrofuran-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.