Description

n-Butyloxycarbonyl-Phenylalanyl-Dehydroleucyl-Valine Methyl Ester is a protected peptide derivative, specifically a Boc-protected tripeptide methyl ester containing a dehydroamino acid residue. This compound is a critical building block in advanced peptide synthesis, offering precise control over molecular structure and sequence. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled assembly of longer, complex peptide chains in both research and process development.
• Pharmaceutical Research: Serves as a precursor in the synthesis of potential drug candidates, particularly those targeting protease inhibition or requiring specific conformational constraints.
• Peptidomimetic Development: The dehydroleucine residue introduces structural rigidity, making it valuable for creating stable peptide analogs with enhanced metabolic stability.
• Bioconjugation & Labeling: The reactive ester and protected amine functionalities allow for site-specific modifications and labeling of biomolecules.
• Chemical Biology Probes: Used to construct specialized peptides for studying enzyme mechanisms, protein-protein interactions, and cellular signaling pathways.

Basic Information

Product Name	n-Butyloxycarbonyl-Phenylalanyl-Dehydroleucyl-Valine Methyl Ester
CAS No.	129229-16-9
Molecular Formula	C26H37N3O6
Molecular Weight	487.59 g/mol
Synonyms	Boc-Phe-δLeu-Val-OMe; Boc-L-Phenylalanyl-dehydro-L-leucyl-L-valine Methyl Ester; N-(tert-Butoxycarbonyl)-L-phenylalanyl-(E)-dehydroleucyl-L-valine Methyl Ester; (E)-Boc-Phe-δLeu-Val-OMe; Boc-Phe-(E)-δLeu-Val-OMe; Peptide Synthesis Intermediate 129229-16-9; Protected Tripeptide Ester
EINECS	Contact for details

Quality Control

Every batch of n-Butyloxycarbonyl-Phenylalanyl-Dehydroleucyl-Valine Methyl Ester is produced and tested under strict quality management protocols to ensure consistency and purity suitable for research and development applications. We provide comprehensive analytical data, including HPLC chromatograms and spectroscopic profiles (NMR, MS). A Certificate of Analysis (COA) detailing purity, identity, and specific impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and open flame.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.