Description

L-(+)-Threo-2-(N,n-Dimethylamino)-1-(4-Aminophenyl)-1,3-Propanediol is a high-purity chiral amino alcohol building block of significant importance in advanced organic synthesis. This compound matters for its role as a critical intermediate in the production of active pharmaceutical ingredients (APIs), particularly for drugs requiring specific stereochemical configurations. Pharmaceutical, agrochemical, and fine chemical research and development teams need it to create novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex APIs, including potential antidepressants, antivirals, and cardiovascular agents.
• Asymmetric Catalyst Ligand: Used in the development of chiral ligands for catalytic asymmetric reactions, enhancing enantioselectivity.
• Agrochemical Synthesis: Serves as a building block for creating novel, optically active pesticides and herbicides.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, flavors, and fragrances requiring precise stereochemistry.
• Academic & Industrial Research: A valuable reagent for medicinal chemistry and process chemistry research in both university and corporate R&D labs.
• Diagnostic Agent Precursor: Potential use in synthesizing contrast agents or molecular probes for diagnostic imaging.

Basic Information

Product Name	L-(+)-Threo-2-(N,n-Dimethylamino)-1-(4-Aminophenyl)-1,3-Propanediol
CAS No.	129170-43-0
Molecular Formula	C11H18N2O2
Molecular Weight	210.27 g/mol
Synonyms	(+)-Threo-2-(Dimethylamino)-1-(4-aminophenyl)-1,3-propanediol; L-Threo-DMAPP; (1R,2S)-2-(Dimethylamino)-1-(4-aminophenyl)propane-1,3-diol; (1R,2S)-2-(N,N-Dimethylamino)-1-(4-aminophenyl)-1,3-propanediol; 1-(4-Aminophenyl)-2-(dimethylamino)-1,3-propanediol (L-threo form); DMAPP; 129170-43-0; Amino alcohol intermediate 129170-43-0
EINECS	Contact for details

Quality Control

Our L-(+)-Threo-2-(N,n-Dimethylamino)-1-(4-Aminophenyl)-1,3-Propanediol is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data, including HPLC/GC purity, chiral purity, and identification via spectroscopic methods (IR, NMR). Certificates of Analysis (COA) are available for every batch and provided upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.