Description

1,3-Dihydro-7-Bromo-5-(2-Chlorophenyl)-3-Hydroxy-1-Methyl-2H-1,4-Benzo Diazepin-2-One is a high-purity benzodiazepine derivative, a critical advanced pharmaceutical intermediate. Its value lies in its precise molecular structure, which serves as a key building block for the synthesis of novel therapeutic agents. This compound is essential for research and development laboratories and pharmaceutical manufacturers focused on central nervous system (CNS) drug discovery and production.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the development and manufacturing of active pharmaceutical ingredients (APIs) within the benzodiazepine class.
• Research & Development: Critical for medicinal chemistry research, enabling the synthesis of new chemical entities for biological screening and pharmacological studies.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, GC-MS).
• Process Chemistry: Used in scale-up and optimization studies for the commercial production of specialized therapeutic compounds.

Basic Information

Product Name	1,3-Dihydro-7-Bromo-5-(2-Chlorophenyl)-3-Hydroxy-1-Methyl-2H-1,4-Benzo Diazepin-2-One
CAS No.	129166-25-2
Molecular Formula	C₁₆H₁₂BrClN₂O₂
Molecular Weight	379.64 g/mol
Synonyms	7-Bromo-5-(2-chlorophenyl)-3-hydroxy-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Bromo-5-(o-chlorophenyl)-1-methyl-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 129166-25-2; Bromo-substituted benzodiazepine derivative; 1,4-Benzodiazepin-2-one, 7-bromo-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-1-methyl-
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.