Description

cis-1-Benzoyl-4-Mesyloxy-L-Proline is a high-value, non-natural proline derivative characterized by its specific stereochemistry and functional groups. This compound is a critical chiral building block and intermediate in modern organic synthesis, particularly for the development of pharmaceuticals and bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of complex peptides, enzyme inhibitors, and novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting proteases and other enzymes.
• Peptidomimetic Research: Used to construct constrained peptide analogs and peptidomimetics to enhance metabolic stability and bioavailability.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and the discovery of new therapeutic agents.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective chemical transformations.
• Bioconjugation & Probe Development: The reactive mesyloxy group allows for further functionalization, making it useful in creating chemical probes for biological studies.

Basic Information

Product Name	cis-1-Benzoyl-4-Mesyloxy-L-Proline
CAS No.	129155-63-1
Molecular Formula	C13H15NO6S
Molecular Weight	313.33 g/mol
Synonyms	L-Proline, 1-benzoyl-4-[(methylsulfonyl)oxy]-, cis-; (2S,4S)-1-Benzoyl-4-[(methylsulfonyl)oxy]-2-pyrrolidinecarboxylic Acid; 4-Mesyloxy-L-proline Benzamide Derivative; cis-4-O-Mesyl-L-proline Benzoyl Ester; 1-Benzoyl-4-methanesulfonyloxy-L-proline; Bz-4-OMs-L-Pro-OH (cis); (4S)-1-Benzoyl-4-[(methylsulfonyl)oxy]-L-proline
EINECS	Contact for details

Quality Control

Our cis-1-Benzoyl-4-Mesyloxy-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical development. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); ensure the container is kept tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (cis isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.