Description

Boc-Pro-Dehydro-Phe-Gly-Oh (CAS NO 129119-97-7) is a protected, non-natural amino acid derivative featuring a dehydro-phenylalanine residue, which introduces conformational rigidity into peptide chains. This compound is a critical building block for advanced peptide synthesis, enabling the development of novel bioactive molecules with enhanced stability and specific biological activity profiles. It is primarily utilized by pharmaceutical R&D teams, peptide manufacturers, and academic researchers focused on drug discovery, enzyme inhibitors, and structural biology studies.

Application

• Pharmaceutical Research & Development: A key intermediate in the synthesis of conformationally constrained peptide-based drug candidates, particularly for targeting proteases and GPCRs.
• Peptide Library Synthesis: Used in combinatorial chemistry to create diverse peptide libraries for high-throughput screening against biological targets.
• Enzyme Inhibitor Design: The dehydro-amino acid moiety serves as a non-hydrolyzable mimic or transition-state analog in the design of potent enzyme inhibitors.
• Structural Probes: Employed to study peptide and protein folding, stability, and structure-activity relationships (SAR) by introducing specific conformational constraints.
• Bioconjugation & Labeling: Can be used as a specialty linker or handle for the site-specific modification of peptides and proteins.
• Academic & Contract Research: Essential reagent for universities and CROs conducting fundamental research in peptide chemistry and medicinal chemistry.

Basic Information

Product Name	Boc-Pro-Dehydro-Phe-Gly-Oh
CAS No.	129119-97-7
Molecular Formula	C21H27N3O6
Molecular Weight	417.46 g/mol
Synonyms	Boc-Pro-δPhe-Gly-OH; (S)-2-((S)-2-((tert-Butoxycarbonyl)amino)-3,3-diphenylpropanamido)-5-oxopentanoic acid; tert-Butyl (2S)-1-[(2S)-2-[(2S)-2-(tert-butoxycarbonylamino)-3,3-diphenylprop-2-enoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carboxylate (related IUPAC); Boc-L-Prolyl-dehydro-L-phenylalanyl-glycine; Boc-Pro-δZ-Phe-Gly-OH; N-(tert-Butoxycarbonyl)-L-prolyl-(Z)-dehydro-L-phenylalanyl-glycine; Protected Dehydro-Phenylalanine Peptide Fragment
EINECS	Contact for details

Quality Control

Our Boc-Pro-Dehydro-Phe-Gly-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and structural confirmation via NMR and MS. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.