Description

(R)-6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Carboxylicacid is a high-purity chiral building block and key pharmaceutical intermediate of significant commercial interest. This compound is valued for its role in the synthesis of complex, biologically active molecules, particularly in the development of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the production of advanced therapeutics.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Chiral Building Block: Used in asymmetric synthesis to construct complex molecular architectures with high enantiomeric purity.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the research and scale-up production of enantiomerically pure APIs.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization processes.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for the production of clinical trial materials and commercial drug substances.
• Process Chemistry: Utilized in route scouting and process development for efficient, scalable synthetic pathways.

Basic Information

Product Name	(R)-6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Carboxylicacid
CAS No.	129101-37-7
Molecular Formula	C10H9FO3
Molecular Weight	196.18 g/mol
Synonyms	(R)-6-Fluorochroman-2-carboxylic acid; (2R)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid; (R)-6-Fluorochromane-2-carboxylic Acid; 6-Fluoro-(R)-chroman-2-carboxylic acid; (R)-6-Fluoro-2-chromancarboxylic acid; (2R)-6-Fluoro-3,4-dihydro-2H-chromene-2-carboxylic acid; (R)-6-Fluoro-3,4-dihydro-2H-chromene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our (R)-6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Carboxylicacid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive analytical data to support its use in regulated environments. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.