Description

2H-1-Benzopyran-2-Carboxylic Acid, 6-Fluoro-3,4-Dihydro-, (2S)- is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a key building block in the development of active pharmaceutical ingredients (APIs) and other fine chemicals, where its specific stereochemistry is critical for biological activity. Pharmaceutical R&D laboratories and fine chemical manufacturers need this material for the synthesis of complex molecules, particularly in therapeutic areas requiring fluorinated chroman scaffolds.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially in central nervous system (CNS) and cardiovascular research.
• Asymmetric Synthesis: Used in stereoselective reactions to construct complex molecular architectures due to its defined (2S) configuration.
• Fluorinated Compound Research: Serves as a valuable substrate in medicinal chemistry for studying the effects of fluorine substitution on drug metabolism and potency.
• Chiral Catalyst or Ligand Precursor: Can be utilized in the development of new chiral catalysts or ligands for enantioselective transformations.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Academic & Industrial R&D: Fundamental research in organic chemistry and process development for scaling up synthetic routes.

Basic Information

Product Name	2H-1-Benzopyran-2-Carboxylic Acid, 6-Fluoro-3,4-Dihydro-, (2S)-
CAS No.	129101-36-6
Molecular Formula	C10H9FO3
Molecular Weight	196.18 g/mol
Synonyms	(2S)-6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid; (S)-6-Fluoro-3,4-dihydro-2H-chromene-2-carboxylic acid; (2S)-6-Fluoro-3,4-dihydro-2H-chromene-2-carboxylic acid; 6-Fluoro-(S)-chroman-2-carboxylic acid; (S)-6-Fluorochroman-2-carboxylic Acid; 129101-36-6; (2S)-6-Fluorochroman-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 2H-1-Benzopyran-2-Carboxylic Acid, 6-Fluoro-3,4-Dihydro-, (2S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.