Description

Defluoro Nebivolol is a key pharmaceutical intermediate and a structural analog of the β-blocker Nebivolol, distinguished by the absence of a fluorine atom. This compound is critical for research and development in cardiovascular drug discovery, enabling the study of structure-activity relationships and the synthesis of novel therapeutic candidates. It is primarily utilized by pharmaceutical R&D laboratories, API manufacturers, and academic institutions focused on cardiology and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block in the research and synthesis of novel β-adrenergic blocking agents and related cardiovascular drugs.
• Reference Standard: Used as an analytical standard in quality control laboratories for method development and impurity profiling of Nebivolol and its derivatives.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies to understand the impact of fluorination on drug potency, selectivity, and metabolic stability.
• Process Chemistry Development: Serves as a model compound for developing and optimizing synthetic routes for complex benzopyran-based molecules under non-fluorinated conditions.
• Academic Research: Employed in university and institutional labs for pharmacological studies and educational purposes in advanced organic synthesis.

Basic Information

Product Name	Defluoro Nebivolol
CAS No.	129101-34-4
Molecular Formula	C22H25F2NO4
Molecular Weight	405.44 g/mol
Synonyms	1-(6-Fluorochroman-2-yl)-2-{[2-(6-fluorochroman-2-yl)-2-hydroxyethyl]amino}ethanol (Defluoro analog); Desfluoro Nebivolol; Nebivolol Impurity; UNII-5T61941EGL; 2,2'-((2RS,2'RS)-2,2'-(Azanediyl)bis(1-hydroxyethane-2,1-diyl))bis(6-fluorochroman); (RS,RS)-Nebivolol Desfluoro Analog
EINECS	Contact for details

Quality Control

Our Defluoro Nebivolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.