Description

Didefluoro Nebivolol CAS NO 129101-33-3 is a key pharmaceutical intermediate and a structural analog of the β-blocker Nebivolol, distinguished by the absence of two fluorine atoms. This compound is of critical importance in the research and development of novel cardiovascular therapeutics and for the synthesis of related active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions focused on cardiology and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Nebivolol analogs and other β-adrenergic blocking agents.
• Research & Development: Used in preclinical and clinical research to study structure-activity relationships (SAR) and develop new cardiovascular drugs.
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of advanced pharmaceutical intermediates.
• Metabolite Studies: Utilized as a standard in pharmacokinetic and metabolic profiling studies of β-blocker drugs.

Basic Information

Product Name	Didefluoro Nebivolol
CAS No.	129101-33-3
Molecular Formula	C22H25F2NO4
Molecular Weight	405.44 g/mol
Synonyms	1-(6-Fluorochroman-2-yl)-2-{[2-(6-fluorochroman-2-yl)-2-hydroxyethyl]amino}ethanol; Didesfluoro Nebivolol; Nebivolol Didefluoro Analog; UNII-9PJ7A6V5JN; (RS)-1,1'-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]; 2,2'-[Azanediylbis(methylene)]bis(6-fluorochroman-2-methanol)
EINECS	Contact for details

Quality Control

Our Didefluoro Nebivolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided for full traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.