Description

tert-Butyl [(1R)-2-Amino-1-Benzyl-2-Oxoethyl]Carbamate is a chiral, protected amino acid derivative of significant importance in advanced organic synthesis. This compound serves as a critical high-purity building block for the construction of complex peptide-based molecules and active pharmaceutical ingredients (APIs). It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of therapeutic peptides, protease inhibitors, and other bioactive compounds where stereochemical integrity is paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drugs and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in the development of novel inhibitors for enzymes like HIV protease and renin.
• Peptide Chemistry: Serves as a protected amino acid building block for solid-phase and solution-phase peptide synthesis (SPPS).
• Asymmetric Synthesis: Employed in the preparation of enantiomerically pure compounds for medicinal chemistry and catalysis studies.
• Chemical Biology: Utilized in the synthesis of labeled peptides and probes for studying biological mechanisms.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing specialized fine chemicals.

Basic Information

Product Name	tert-Butyl [(1R)-2-Amino-1-Benzyl-2-Oxoethyl]Carbamate
CAS No.	129095-62-1
Molecular Formula	C14H20N2O3
Molecular Weight	264.32 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-2-phenylacetic acid; Boc-D-Phg-OH; N-Boc-D-Phenylglycine; N-(tert-Butoxycarbonyl)-D-phenylglycine; tert-Butyl N-[(1R)-2-amino-1-benzyl-2-oxoethyl]carbamate; (R)-2-(Boc-amino)-2-phenylacetic acid; D-Phenylglycine, N-Boc-; BOC-D-PHG-OH
EINECS	Contact for details

Quality Control

Our tert-Butyl [(1R)-2-Amino-1-Benzyl-2-Oxoethyl]Carbamate is produced under strict quality management systems to ensure batch-to-batch consistency and high chemical purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥98.0% by HPLC), chiral purity, and impurity profiles. We support development and commercial projects requiring compliance with ICH guidelines and can provide material suitable for use in GMP-regulated environments upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.