Description

(2S)-6-Fluoro-2-(Oxiran-2-Yl)Chromane is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is valued for its unique structural framework, which incorporates a chromane core, a fluorine substituent, and a reactive epoxide (oxirane) group, enabling its use in sophisticated synthetic pathways. It is primarily sought after by research institutions and manufacturers in the pharmaceutical industry for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex, fluorinated molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• API Development: Serves as a critical precursor in the research and production of fluorinated active pharmaceutical ingredients, leveraging the metabolic stability often imparted by fluorine atoms.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Asymmetric Synthesis: The chiral center and reactive epoxide make it a valuable substrate for developing new catalytic asymmetric reactions in process chemistry.
• Chemical Reference Standard: Employed as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	(2S)-6-Fluoro-2-(Oxiran-2-Yl)Chromane
CAS No.	129050-29-9
Molecular Formula	C12H11FO2
Molecular Weight	206.21 g/mol
Synonyms	(2S)-6-Fluoro-2-(oxiran-2-yl)-2H-chromene; (2S)-6-Fluoro-2-(oxiranyl)-2H-1-benzopyran; 6-Fluoro-(2S)-2-(oxiran-2-yl)chromane; (S)-6-Fluoro-2-(oxiran-2-yl)chroman; 129050-29-9; (2S)-6-Fluoro-2-(2-oxiranyl)chromane; 2H-1-Benzopyran, 6-fluoro-2-(oxiran-2-yl)-, (2S)-
EINECS	Contact for details

Quality Control

Our (2S)-6-Fluoro-2-(Oxiran-2-Yl)Chromane is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound may be sensitive to moisture and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.