Description

6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Carboxylic Acid is a high-purity fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because it serves as a critical chiral intermediate for constructing complex molecules with tailored biological activity. Pharmaceutical R&D and fine chemical manufacturers need it for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new drug candidates, especially in central nervous system (CNS) and cardiovascular therapies.
• Agrochemical Synthesis: Used in the creation of advanced, fluorinated active ingredients for crop protection products, leveraging the fluorine atom's ability to enhance bioavailability and stability.
• Ligand & Catalyst Development: Serves as a precursor for designing novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and advanced organic materials where the benzopyran core imparts specific optical or electronic properties.
• Academic & Contract Research: Essential for medicinal chemistry programs and process development in university labs and CROs/CDMOs.

Basic Information

Product Name	6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Carboxylic Acid
CAS No.	129050-20-0
Molecular Formula	C10H9FO3
Molecular Weight	196.17 g/mol
Synonyms	6-Fluoro-3,4-dihydro-2H-chromene-2-carboxylic acid; 6-Fluorochroman-2-carboxylic acid; 2H-1-Benzopyran-2-carboxylic acid, 6-fluoro-3,4-dihydro-; 129050-20-0; 6-Fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid; 6-Fluorodihydrochroman-2-carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 6-Fluoro-3,4-Dihydro-2H-1-Benzopyran-2-Carboxylic Acid is produced under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC purity data, to ensure the material meets your specific R&D or production requirements. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.