Description

1-(2-tert-Butoxycarbonylamino-1-Oxopropyl)Octahydrocyclopenta[B]Pyrrole-2-Caroxylic Acid, Benzyl Ester is a sophisticated chiral building block and advanced pharmaceutical intermediate of significant commercial interest. Its complex, constrained bicyclic structure makes it a valuable scaffold for medicinal chemistry research and the synthesis of novel active pharmaceutical ingredients (APIs). This compound is primarily sought by pharmaceutical R&D organizations and fine chemical manufacturers engaged in developing peptidomimetics and other complex therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the multi-step synthesis of complex drug candidates, particularly those targeting neurological and metabolic disorders.
• Peptidomimetic Research: Serves as a constrained proline analog for designing novel peptide-like molecules with enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Scaffold: Used as a core structural element for constructing combinatorial libraries to screen for new biological activity.
• Process Chemistry Development: Employed in route scouting and optimization for the commercial-scale production of target APIs.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs specializing in custom synthesis for client drug discovery programs.
• Academic Research: Utilized in university and institutional labs for studies in asymmetric synthesis and heterocyclic chemistry.

Basic Information

Product Name	1-(2-tert-Butoxycarbonylamino-1-Oxopropyl)Octahydrocyclopenta[B]Pyrrole-2-Caroxylic Acid, Benzyl Ester
CAS No.	129048-22-2
Molecular Formula	C23H32N2O5
Molecular Weight	416.52 g/mol
Synonyms	Boc-Octahydrocyclopenta[b]pyrrole-2-carboxylic Acid Benzyl Ester; (3aS,7aR)-1-[(2S)-2-[(tert-Butoxycarbonyl)amino]propanoyl]octahydro-1H-cyclopenta[b]pyrrole-2-carboxylic Acid Benzyl Ester; Benzyl (3aS,7aR)-1-[(2S)-2-[(tert-Butoxycarbonyl)amino]propanoyl]octahydro-1H-cyclopenta[b]pyrrole-2-carboxylate; (3aS,7aR)-1-[(2S)-2-[(tert-Butoxycarbonyl)amino]propanoyl]octahydro-1H-cyclopenta[b]pyrrole-2-carboxylic Acid Phenylmethyl Ester; BOC-Protected Cyclopentapyrrolidine Derivative; Advanced Proline Analog Intermediate.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management protocols. Every batch is characterized and tested using advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and chiral integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our facilities and processes are designed to meet the exacting standards required for GMP-grade intermediates used in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is moisture-sensitive; the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.