Description

3-Isopropoxy-4-(Tributylstannyl)-1,2-Cyclobutenedioneliebeskind Reagent is a specialized organotin reagent used in advanced organic synthesis. This compound is a critical building block for the efficient formation of carbon-carbon bonds, particularly in complex molecule construction. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel compounds and active pharmaceutical ingredients (APIs).

Application

• Stille Cross-Coupling Reactions: A key reagent for palladium-catalyzed cross-coupling with organic halides or triflates to form new C-C bonds.
• Pharmaceutical Intermediate Synthesis: Used in the construction of complex heterocycles and bioactive molecules during drug discovery and development.
• Agrochemical Research: Employed in the synthesis of novel pesticides, herbicides, and plant growth regulators.
• Material Science: Facilitates the synthesis of organic electronic materials, such as those used in OLEDs and semiconductors.
• Natural Product Synthesis: Enables the efficient and stereoselective synthesis of complex natural products and their analogs.
• Methodology Development: Serves as a standard reagent in academic and industrial labs for developing new catalytic coupling methodologies.

Basic Information

Item	Details
Product Name	3-Isopropoxy-4-(Tributylstannyl)-1,2-Cyclobutenedioneliebeskind Reagent
CAS No.	129034-70-4
Molecular Formula	C19H34O3Sn
Molecular Weight	445.18 g/mol
Synonyms	3-Isopropoxy-4-(tributylstannyl)cyclobut-3-ene-1,2-dione; Liebeskind Reagent; 4-(Tributylstannyl)-3-isopropoxy-3-cyclobutene-1,2-dione; Tributyl(3-isopropoxy-1,2-dioxocyclobut-3-en-4-yl)stannane; 1,2-Cyclobutenedione, 3-isopropoxy-4-(tributylstannyl)-; Stannane, tributyl[3-(1-methylethoxy)-1,2-dioxo-3-cyclobuten-4-yl]-
EINECS	Contact for details

Quality Control

Our 3-Isopropoxy-4-(Tributylstannyl)-1,2-Cyclobutenedioneliebeskind Reagent is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All batches are characterized by NMR (1H, 13C, 119Sn), FT-IR, and elemental analysis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a cool, dry, well-ventilated place. Keep away from heat, sparks, and open flame. Due to its sensitivity to oxidation and light, prolonged exposure to air or ambient light should be avoided.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Tin (Sn) Content	26.5 - 27.5 %
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.