Description

2',3',5'-Tri-o-Acetyl-5-Fluorocytidine is a key fluorinated nucleoside derivative, serving as a crucial protected intermediate in the synthesis of advanced pharmaceutical compounds. Its primary value lies in enabling the precise and efficient construction of modified oligonucleotides and nucleoside analogs, which are essential for antiviral and anticancer research and development. This high-purity intermediate is specifically required by pharmaceutical R&D laboratories, fine chemical manufacturers, and CDMOs (Contract Development and Manufacturing Organizations) engaged in the production of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of antiviral and anticancer nucleoside analogs, such as Sofosbuvir and related prodrugs.
• Oligonucleotide Synthesis: Used as a protected monomer for the solid-phase or solution-phase synthesis of fluorinated oligonucleotides for research and therapeutic applications.
• Biochemical Research: Employed in studies investigating RNA structure, function, and metabolism, particularly where fluorine labeling or substitution is required.
• Prodrug Development: Acts as a precursor for the development of nucleoside prodrugs designed to improve bioavailability and targeted delivery.
• Antiviral Agent Synthesis: Integral to the manufacturing process of nucleotide-based drugs targeting hepatitis C virus (HCV) and other viral pathogens.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	2',3',5'-Tri-o-Acetyl-5-Fluorocytidine
CAS No.	128963-10-0
Molecular Formula	C15H18FN3O8
Molecular Weight	387.32 g/mol
Synonyms	5-Fluoro-2',3',5'-tri-O-acetylcytidine; 1-(2,3,5-Tri-O-acetyl-β-D-ribofuranosyl)-5-fluorocytosine; 5-Fluorocytidine 2',3',5'-triacetate; 2',3',5'-Tri-O-acetyl-5-fluorocytidine; 5-Fluoro-1-[(2R,3R,4R,5R)-3,4-diacetyloxy-5-(acetyloxymethyl)oxolan-2-yl]pyrimidin-2-one; 5-FC-2',3',5'-triacetate; 5-Fluorocytidine triacetate
EINECS	Contact for details

Quality Control

Our 2',3',5'-Tri-o-Acetyl-5-Fluorocytidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.