Description

12(4-Nitrobenzyl)-1,4,7,10-Tetraazacyclotridecane-1,4,7-Triacetic Acid CAS NO 128924-92-5 is a specialized macrocyclic chelating agent, a key intermediate in the synthesis of advanced contrast agents for medical imaging. Its core value lies in its ability to form highly stable complexes with paramagnetic metal ions, which is critical for enhancing image clarity and diagnostic safety. This compound is essential for research institutions and manufacturers in the pharmaceutical and biotechnology sectors developing next-generation MRI contrast media and radiopharmaceuticals.

Application

• MRI Contrast Agent Precursor: Primary intermediate in the synthesis of gadolinium(III)-based contrast agents for magnetic resonance imaging (MRI).
• Radiopharmaceutical Development: Chelator for radiolabeling with isotopes like Gallium-68 or Lutetium-177 for positron emission tomography (PET) and targeted radionuclide therapy.
• Research Chemical: Used in academic and industrial R&D for studying macrocyclic ligand chemistry, metal complex stability, and new diagnostic platforms.
• Pharmaceutical Intermediate: Critical building block in the multi-step synthesis of approved and investigational diagnostic pharmaceuticals.
• Metal Scavenging & Separation: Potential application in analytical chemistry for the selective extraction or detection of specific metal ions.

Basic Information

Item	Details
Product Name	12(4-Nitrobenzyl)-1,4,7,10-Tetraazacyclotridecane-1,4,7-Triacetic Acid
CAS No.	128924-92-5
Molecular Formula	C22H33N5O8
Molecular Weight	495.53 g/mol
Synonyms	12-(4-Nitrobenzyl)-1,4,7,10-tetraazacyclotridecane-1,4,7-triacetic acid; 12-(p-Nitrobenzyl)-1,4,7,10-tetraazacyclotridecane-1,4,7-triacetic acid; 12-(4-Nitrobenzyl)-NOTA; p-Nitrobenzyl-NOTA; 12-(4-Nitrobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid (common misnomer); NOTA-(p-NO2-Bn); 1,4,7-Triazacyclononane-1,4,7-triacetic acid, 12-(4-nitrobenzyl)- derivative; Bz-NOTA-Nitro
EINECS	Contact for details

Quality Control

Our production of 12(4-Nitrobenzyl)-1,4,7,10-Tetraazacyclotridecane-1,4,7-Triacetic Acid adheres to stringent quality protocols suitable for pharmaceutical intermediate applications. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure consistency and traceability. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.