Description

12-(4-Nitrobenzyl)-1,4,7,10-Tetraazacyclotridecane-1,4,7,10-Tetraacetic Acid is a specialized bifunctional chelating agent derived from the cyclen (1,4,7,10-tetraazacyclododecane) macrocycle. This compound is engineered for the stable complexation of trivalent metal ions, most notably gadolinium (Gd³⁺), making it a critical intermediate in advanced diagnostic imaging. It is primarily utilized by research institutions and pharmaceutical developers focused on next-generation contrast agents for Magnetic Resonance Imaging (MRI). The nitrobenzyl moiety provides a versatile handle for further chemical conjugation, enabling the development of targeted imaging probes.

Application

• MRI Contrast Agent Precursor: Serves as a key synthetic intermediate for developing gadolinium-based contrast agents (GBCAs) with enhanced relaxivity and stability.
• Bifunctional Chelator (BFC) for Radiopharmaceuticals: Used in research for labeling antibodies, peptides, or other targeting vectors with diagnostic or therapeutic radionuclides (e.g., ⁶⁸Ga, ¹¹¹In, ¹⁷⁷Lu).
• Molecular Imaging Probe Development: Enables the creation of targeted imaging agents for cancer research, cardiovascular disease studies, and neurological disorder diagnostics.
• Chemical Biology Research: Employed in studies involving metal ion transport, sensing, and catalysis due to its high-affinity, multidentate coordination geometry.
• Pharmaceutical Intermediate: A critical building block in the synthesis of novel macrocyclic polyaminocarboxylate ligands for various biomedical applications.

Basic Information

Product Name	12-(4-Nitrobenzyl)-1,4,7,10-Tetraazacyclotridecane-1,4,7,10-Tetraacetic Acid
CAS No.	128924-91-4
Molecular Formula	C₂₅H₃₆N₆O₁₀
Molecular Weight	580.59 g/mol
Synonyms	p-Nitrobenzyl-DOTA; 4-Nitrobenzyl-DOTA; 1,4,7,10-Tetraazacyclotridecane-1,4,7,10-tetraacetic acid, 12-(4-nitrobenzyl)-; DOTA-Nitrobenzyl; NB-DOTA; 12-(4-Nitrobenzyl)-1,4,7,10-tetraazacyclotridecane-N,N',N'',N'''-tetraacetic acid; Bifunctional DOTA derivative
EINECS	Contact for details

Quality Control

Our 12-(4-Nitrobenzyl)-1,4,7,10-Tetraazacyclotridecane-1,4,7,10-Tetraacetic Acid is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.