Description

Ethanone, 2-Chloro-1-(4-Hydroxycyclohexyl)-, trans- (9Ci) is a high-purity, synthetically valuable chiral intermediate featuring a functionalized cyclohexyl ring system. This compound matters as a critical building block in the synthesis of complex pharmaceutical molecules, where its defined stereochemistry and reactive ketone and chloro groups enable precise chemical transformations. It is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries for creating novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Asymmetric Synthesis: Utilized in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Agrochemical Research: Serves as a precursor in the development of advanced, biologically active compounds for crop protection.
• Ligand and Catalyst Development: Used to synthesize novel chiral ligands and organocatalysts for catalytic processes.
• Material Science Precursor: Investigated for the synthesis of specialty polymers and advanced organic materials with specific functional properties.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and custom synthesis projects.

Basic Information

Product Name	Ethanone, 2-Chloro-1-(4-Hydroxycyclohexyl)-, trans- (9Ci)
CAS No.	128882-64-4
Molecular Formula	C8H13ClO2
Molecular Weight	176.64 g/mol
Synonyms	trans-2-Chloro-1-(4-hydroxycyclohexyl)ethanone; 2-Chloro-1-(trans-4-hydroxycyclohexyl)ethanone; 1-(trans-4-Hydroxycyclohexyl)-2-chloroethanone; (1r,4r)-2-Chloro-1-(4-hydroxycyclohexyl)ethanone; 2-Chloro-1-(4-hydroxycyclohexyl)ethanone (trans-); 128882-64-4; 2-Chloro-1-(4-hydroxycyclohexyl)ethan-1-one
EINECS	Contact for details

Quality Control

Our Ethanone, 2-Chloro-1-(4-Hydroxycyclohexyl)-, trans- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.