Description

[1-[(E)-4-Phenoxybut-2-Enyl]-4-Phenyl-4-Piperidyl] Propanoate Hydrochloride is a high-purity pharmaceutical intermediate and research chemical of significant synthetic interest. This compound matters for its role as a key building block in the development of active pharmaceutical ingredients (APIs), particularly within the central nervous system (CNS) therapeutic area. Pharmaceutical manufacturers, advanced research institutions, and fine chemical synthesis specialists require this material for its precise chemical structure to ensure the efficacy and purity of final drug products.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex active pharmaceutical ingredients (APIs), especially for neurological and analgesic applications.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the discovery of new therapeutic agents.
• Process Chemistry: Serves as a standard or reference compound in the development and optimization of scalable synthetic routes.
• Analytical Standard: Employed as a high-purity reference standard in quality control (QC) laboratories for method development and validation (e.g., HPLC, GC).
• Academic Research: Utilized in university and institutional labs for advanced studies in organic synthesis and pharmacology.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, non-commercial compounds for client-specific projects.

Basic Information

Product Name	[1-[(E)-4-Phenoxybut-2-Enyl]-4-Phenyl-4-Piperidyl] Propanoate Hydrochloride
CAS No.	128864-81-3
Molecular Formula	C24H30ClNO3
Molecular Weight	415.96 g/mol
Synonyms	1-[(E)-4-Phenoxybut-2-en-1-yl]-4-phenylpiperidin-4-yl propionate hydrochloride; 4-Phenyl-1-[trans-4-(phenoxy)-2-butenyl]-4-piperidinol propionate hydrochloride; Fentanyl isostere intermediate; 4-Phenyl-4-piperidinol propionate derivative; Norfentanyl analog intermediate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our [1-[(E)-4-Phenoxybut-2-Enyl]-4-Phenyl-4-Piperidyl] Propanoate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D and intermediate use. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require desiccant or storage under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.