Description

5-Iodo-2-Hydroxyglyburide is a halogenated derivative of the sulfonylurea drug glyburide, primarily utilized as a key intermediate in pharmaceutical research and development. This compound is of significant value for medicinal chemists exploring structure-activity relationships and developing novel therapeutic agents targeting metabolic disorders. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors focused on diabetes research and drug discovery.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel sulfonylurea-based drug candidates and analogs.
• Metabolic Research: Used in biochemical and pharmacological studies to investigate insulin secretion pathways and pancreatic β-cell function.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Medicinal Chemistry: Employed in lead optimization and molecular modification programs to enhance drug potency, selectivity, or pharmacokinetic properties.
• Academic Research: Utilized in university and institutional labs for fundamental research on diabetes and endocrine system modulation.
• Bioconjugation Studies: Potential use in creating labeled probes or conjugates for biological imaging or targeting studies due to the reactive iodine moiety.

Basic Information

Product Name	5-Iodo-2-Hydroxyglyburide
CAS No.	128836-54-4
Molecular Formula	C23H28IN3O6S
Molecular Weight	601.45 g/mol
Synonyms	5-Iodo-2-hydroxyglibenclamide; 1-[4-[2-(5-Iodo-2-hydroxybenzamido)ethyl]benzenesulfonyl]-3-cyclohexylurea; N-[4-[2-[[[[(Cyclohexylamino)carbonyl]amino]sulfonyl]methyl]phenyl]ethyl]-5-iodo-2-hydroxybenzamide; Iodohydroxyglyburide; 5-I-Glyburide; Glyburide iodo derivative
EINECS	Contact for details

Quality Control

Our 5-Iodo-2-Hydroxyglyburide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and mass spectrometry. While produced to high standards, this product is typically offered as a research-grade chemical and not currently certified to USP/EP pharmacopeial monographs unless specified.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and hygroscopic; therefore, handling under inert atmosphere and desiccated conditions is recommended for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.