Description

(R)-n-Boc-5-Methoxycarbonyl-2-Pyrrolidinone CAS NO 128811-48-3 is a high-purity, chiral pyrrolidinone derivative, serving as a critical advanced pharmaceutical intermediate and building block in organic synthesis. Its value lies in its role as a precursor for synthesizing complex molecules with defined stereochemistry, essential for developing active pharmaceutical ingredients (APIs) and fine chemicals. This compound is primarily needed by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) focused on producing chiral drugs and bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of protease inhibitors, antiviral agents, and other bioactive molecules.
• Asymmetric Synthesis: Used in the construction of complex natural products and novel chemical entities requiring precise stereocontrol.
• Peptidomimetics Research: Serves as a constrained scaffold in the design and development of peptide-like drug candidates.
• Agrochemical Development: Intermediate in the synthesis of chiral active ingredients for crop protection products.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry and catalysis.
• Custom Synthesis: Starting material for contract research and manufacturing services (CRAMS) to produce client-specific target molecules.

Basic Information

Product Name	(R)-n-Boc-5-Methoxycarbonyl-2-Pyrrolidinone
CAS No.	128811-48-3
Molecular Formula	C12H19NO5
Molecular Weight	257.28 g/mol
Synonyms	(R)-1-(tert-Butoxycarbonyl)-5-(methoxycarbonyl)-2-pyrrolidinone; (R)-1-Boc-5-(methoxycarbonyl)-2-pyrrolidinone; (R)-5-Methoxycarbonyl-1-Boc-2-pyrrolidinone; (R)-1-tert-Butyl 5-methyl 2-oxopyrrolidine-1,5-dicarboxylate; (R)-N-Boc-5-(Methoxycarbonyl)-2-pyrrolidinone; (R)-N-Boc-5-Carbomethoxy-2-pyrrolidinone; (R)-5-Methoxycarbonyl-1-(tert-butoxycarbonyl)-2-pyrrolidinone
EINECS	Contact for details

Quality Control

Our (R)-n-Boc-5-Methoxycarbonyl-2-Pyrrolidinone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting R&D and cGMP-grade standards. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.