Description

Boc-3,5-Diiodo-Tyr-Ome is a protected, iodinated tyrosine derivative, specifically the tert-butyloxycarbonyl (Boc) protected methyl ester of 3,5-diiodotyrosine. This compound is a crucial advanced pharmaceutical intermediate and a versatile building block in organic synthesis, valued for its role in introducing the unique structural and electronic properties of diiodotyrosine into target molecules. It is primarily utilized by research institutions and pharmaceutical development teams working on peptide-based therapeutics, radiopharmaceuticals, and molecular probes.

Application

• Peptide Synthesis: As a key protected amino acid derivative for the solid-phase or solution-phase synthesis of complex peptides and peptidomimetics.
• Radiopharmaceutical Precursor: Serves as a precursor for the synthesis of iodine-123 or iodine-131 labeled compounds used in diagnostic imaging and targeted radiotherapy.
• Thyroid Hormone Analog Research: Used in the research and development of novel analogs of thyroid hormones (T3, T4) and related bioactive molecules.
• Bioconjugation & Probe Development: Acts as a building block for creating fluorescent, affinity, or other functional probes for biochemical and cellular studies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to investigate the role of halogenated aromatic rings in drug-receptor interactions.
• Chemical Biology: Utilized to incorporate stable iodine atoms as heavy atom labels or spectroscopic handles in biomolecules.

Basic Information

Product Name	Boc-3,5-Diiodo-Tyr-Ome
CAS No.	128781-80-6
Molecular Formula	C15H19I2NO5
Molecular Weight	547.12 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-3,5-diiodo-L-tyrosine methyl ester; Boc-3,5-diiodotyrosine methyl ester; Methyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-(3,5-diiodo-4-hydroxyphenyl)propanoate; Boc-Tyr(3,5-I2)-OMe; Boc-L-3,5-Diiodotyrosine methyl ester; N-Boc-3,5-diiodo-L-tyrosine methyl ester; (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(3,5-diiodo-4-hydroxyphenyl)propanoate
EINECS	Contact for details

Quality Control

Our Boc-3,5-Diiodo-Tyr-Ome is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Optical Rotation	-10.0° to -15.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.