Description

trans-3-(Boc-Amino)-4-Methoxypyrrolidine is a high-purity, protected pyrrolidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a chemically orthogonal amine functionality, protected by the acid-labile tert-butoxycarbonyl (Boc) group, which is essential for constructing complex molecular architectures with precise stereochemistry. This compound is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of active pharmaceutical ingredients (APIs), novel drug candidates, and other fine chemicals where controlled amine introduction is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug molecules, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Peptidomimetic Chemistry: Used to introduce constrained pyrrolidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a building block for developing novel herbicides, fungicides, and insecticides with specific chiral activity.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands for asymmetric catalysis and organocatalysts.
• Academic and Industrial Research: A valuable reagent for methodological development in organic chemistry and for exploring new chemical space in medicinal chemistry programs.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules under cGMP conditions where applicable.

Basic Information

Product Name	trans-3-(Boc-Amino)-4-Methoxypyrrolidine
CAS No.	128739-92-4
Molecular Formula	C10H20N2O3
Molecular Weight	216.28 g/mol
Synonyms	tert-Butyl (3R,4S)-3-Amino-4-methoxypyrrolidine-1-carboxylate; (3R,4S)-1-(tert-Butoxycarbonyl)-4-methoxy-3-pyrrolidinamine; trans-1-Boc-3-Amino-4-methoxypyrrolidine; (3R,4S)-3-[(tert-Butoxycarbonyl)amino]-4-methoxypyrrolidine; Boc-3-Amino-4-methoxypyrrolidine (trans); (3R,4S)-1-Boc-3-Amino-4-methoxypyrrolidine; trans-N-Boc-3-Amino-4-methoxypyrrolidine
EINECS	Contact for details

Quality Control

Our trans-3-(Boc-Amino)-4-Methoxypyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles are provided with every shipment. We can support development with material produced under ICH Q7 compliant guidelines for advanced projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.