Description

(-)-(S)-5-Bromo-n-[(1-Ethyl-2-Pyrrolidinyl)Methyl]-2-Hydroxy-3-Methoxybenzamide CAS NO 128600-22-6 is a high-purity chiral benzamide derivative, specifically the (S)-enantiomer, which is critical for research and development in advanced pharmaceutical synthesis. Its value lies in its role as a sophisticated intermediate or reference standard for the development of active pharmaceutical ingredients (APIs) targeting neurological and psychiatric disorders. This compound is essential for pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions focused on medicinal chemistry and neuroscience.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of novel dopamine receptor antagonists or other central nervous system (CNS) targeted APIs.
• Reference Standard: High-purity material for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug candidate efficacy and selectivity.
• Process Chemistry Development: Serves as a critical intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Neuroscience Research: Investigational tool for studying receptor binding and pharmacological profiles in preclinical models.
• Custom Synthesis: Starting point for the preparation of labeled compounds (e.g., deuterated or C14-labeled) for metabolic and pharmacokinetic studies.

Basic Information

Product Name	(-)-(S)-5-Bromo-n-[(1-Ethyl-2-Pyrrolidinyl)Methyl]-2-Hydroxy-3-Methoxybenzamide
CAS No.	128600-22-6
Molecular Formula	C₁₇H₂₅BrN₂O₃
Molecular Weight	385.30 g/mol
Synonyms	(S)-5-Bromo-N-[(1-ethylpyrrolidin-2-yl)methyl]-2-hydroxy-3-methoxybenzamide; (S)-5-Bromo-2-hydroxy-3-methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide; (-)-S-Bromocriptine Impurity; Bromocriptine Related Compound S; S-(-)-5-Bromo-2-hydroxy-3-methoxy-N-[(1-ethyl-2-pyrrolidinyl)methyl]benzamide; (S)-Bromonorketanserin; Benzamide, 5-bromo-N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-hydroxy-3-methoxy-, (S)-
EINECS	Contact for details

Quality Control

Our production of this advanced pharmaceutical intermediate adheres to stringent quality systems. Every batch is characterized using advanced analytical techniques including HPLC, chiral HPLC, NMR, and mass spectrometry to ensure identity, purity, and enantiomeric excess. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic data and are capable of supplying material that meets the requirements for GMP starting material and ICH Q3A/B guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when possible to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.