Description

(R)-(-)-1,1'-Bi-2-Naphthol Bis(Trifluoromethanesulfonate) is a high-purity chiral reagent and versatile synthetic intermediate. This compound is valued for its role as a chiral catalyst precursor and as a key building block in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is essential for research and development laboratories, as well as production facilities in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Asymmetric Catalysis: Serves as a precursor for chiral Lewis acid catalysts used in enantioselective C-C and C-X bond-forming reactions.
• Pharmaceutical Intermediate: A critical building block in the synthesis of chiral active pharmaceutical ingredients (APIs) and complex natural products.
• Ligand Synthesis: Used to prepare BINOL-derived phosphite, phosphate, and diol ligands for transition metal catalysis.
• Polymer Chemistry: Employed in the development of chiral polymers and materials with specific optical properties.
• Organic Synthesis: Functions as a reactive triflate ester for cross-coupling reactions (e.g., Suzuki, Stille) and nucleophilic substitutions.
• Academic & Industrial R&D: A valuable tool for methodological development in stereoselective synthesis and catalysis research.

Basic Information

Product Name	(R)-(-)-1,1'-Bi-2-Naphthol Bis(Trifluoromethanesulfonate)
CAS No.	128575-34-8
Molecular Formula	C₂₂H₁₂F₆O₆S₂
Molecular Weight	574.45 g/mol
Synonyms	(R)-BINOL Bis(Triflate); (R)-(-)-1,1'-Bi-2-naphthol Ditriflate; (R)-2,2'-Bis(trifluoromethanesulfonyloxy)-1,1'-binaphthyl; (R)-BINOL-Bis(OTf); (R)-1,1'-Binaphthalene-2,2'-diyl bis(trifluoromethanesulfonate); (R)-BINOL Ditriflate; (R)-BINOL Triflate; (R)-H8-BINOL Bis(Triflate) (related derivative)
EINECS	Contact for details

Quality Control

Our (R)-(-)-1,1'-Bi-2-Naphthol Bis(Trifluoromethanesulfonate) is manufactured under strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing key parameters such as chiral purity (HPLC), chemical assay, and impurity profiles. Our quality management system supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.