Description

n-Fmoc-3-(Triphenylmethyl)-L-Histidine is a protected derivative of the essential amino acid L-Histidine, specifically engineered for peptide synthesis. This compound is critical for researchers and manufacturers requiring the precise, sequential assembly of peptides, particularly those containing the histidine residue, while preventing unwanted side reactions. It is an indispensable building block for pharmaceutical R&D, biotechnology, and academic laboratories focused on developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc/tBu strategy, enabling the controlled elongation of peptide chains.
• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Labeling: Used to incorporate histidine residues into proteins or other molecules for site-specific modifications, tags, or probes.
• Research & Development: Essential for academic and industrial research into peptide structure-activity relationships, hormone analogs, and enzyme inhibitors.
• Combinatorial Chemistry Libraries: Employed in the generation of diverse peptide libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	n-Fmoc-3-(Triphenylmethyl)-L-Histidine
CAS No.	128545-09-5
Molecular Formula	C40H35N3O4
Molecular Weight	621.73 g/mol
Synonyms	Fmoc-His(Trt)-OH; N-α-Fmoc-N-π-trityl-L-histidine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-trityl-1H-imidazol-4-yl)propanoic acid; Fmoc-L-histidine(N-π-trityl)-OH; Fmoc-His(Trt)-OH; N-Fmoc-3-trityl-L-histidine; L-Histidine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-3-(triphenylmethyl)-; Fmoc-His(Trt)
EINECS	Contact for details

Quality Control

Our n-Fmoc-3-(Triphenylmethyl)-L-Histidine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP, ISO, and other relevant quality standards for pharmaceutical and research use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and performance. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	-15.0° to -18.0° (c=1, DMF)
Loss on Drying	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.