Description

Carbamic Acid, (2-Fluoro-4-Hydroxy-2-Butenyl)-, 1,1-Dimethylethyl Ester, (Z)- is a specialized fluorinated carbamate derivative, serving as a critical advanced pharmaceutical intermediate (API intermediate) in modern synthetic chemistry. Its unique structure, featuring a Z-configured fluoro-hydroxybutenyl side chain, makes it a valuable building block for constructing complex bioactive molecules. This compound is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fluorinated Compound Synthesis: Serves as a source of a fluorinated moiety for introducing fluorine atoms into target molecules to enhance metabolic stability, bioavailability, and binding affinity.
• Prodrug Development: The tert-butyl carbamate (Boc) protecting group and ester functionality make it suitable for designing prodrug strategies to improve drug delivery.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.
• Agrochemical Research: Potential intermediate in the research and development of new generation fluorinated pesticides and herbicides.

Basic Information

Product Name	Carbamic Acid, (2-Fluoro-4-Hydroxy-2-Butenyl)-, 1,1-Dimethylethyl Ester, (Z)-
CAS No.	128490-22-2
Molecular Formula	C9H16FNO3
Molecular Weight	205.23 g/mol
Synonyms	(Z)-tert-Butyl (2-fluoro-4-hydroxybut-2-en-1-yl)carbamate; (Z)-N-(2-Fluoro-4-hydroxy-2-butenyl)carbamic Acid 1,1-Dimethylethyl Ester; (Z)-Boc-2-fluoro-4-hydroxy-2-butenylamine; tert-Butyl N-[(2Z)-2-fluoro-4-hydroxybut-2-en-1-yl]carbamate; (Z)-2-Fluoro-4-hydroxy-2-butenyl tert-butyl carbamate; (Z)-1-(tert-Butoxycarbonylamino)-2-fluoro-4-hydroxy-2-butene; (Z)-Boc-NH-CH2-CF=CH-CH2OH
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, (2-Fluoro-4-Hydroxy-2-Butenyl)-, 1,1-Dimethylethyl Ester, (Z)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and isomer confirmation, NMR for structural verification, and MS for identity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Isomeric Purity (Z-Isomer)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.