Description

6-Hydroxy Alosetron is a key pharmaceutical intermediate and metabolite of the drug Alosetron. This compound matters for its critical role in the research, development, and quality control of serotonergic agents targeting gastrointestinal disorders. Pharmaceutical manufacturers and advanced research laboratories need it for synthesizing reference standards, conducting metabolic studies, and ensuring batch-to-batch consistency in active pharmaceutical ingredient (API) production.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Alosetron hydrochloride and related therapeutic compounds.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in QC/QA laboratories.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the drug's metabolism and activity profile.
• Impurity Profiling: Serves as a known impurity standard to monitor and control the quality of Alosetron API batches.
• Biochemical Research: Employed in vitro studies to investigate interactions with 5-HT3 receptors and other biological targets.
• Regulatory Submissions: Supports drug master file (DMF) preparation and regulatory documentation for new drug applications.

Basic Information

Product Name	6-Hydroxy Alosetron
CAS No.	128486-89-5
Molecular Formula	C17H18N4O
Molecular Weight	294.35 g/mol
Synonyms	6-Hydroxyalosetron; 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one, 6-Hydroxy Derivative; Alosetron Metabolite; 6-OH-Alosetron; GR 68755C (6-Hydroxy); 1H-Pyrido[4,3-b]indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-, 6-hydroxy-; Lotronex Metabolite
EINECS	Contact for details

Quality Control

Our 6-Hydroxy Alosetron is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and MS, to ensure compliance with high-purity standards suitable for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.