Description

(S)-5,6,7,8-Tetrahydro-6-[Propyl[2-(2-Thienyl)Ethyl]Amino]- 1-Naphthalenol Hydrogen Sulfate (Ester) CAS NO 128478-69-3 is a high-purity, chiral organic compound with a complex naphthalene-thiophene hybrid structure. This compound is of significant value as a key pharmaceutical intermediate or advanced research chemical for the development of novel therapeutic agents. It is primarily required by pharmaceutical R&D and fine chemical synthesis sectors for the production of active pharmaceutical ingredients (APIs) and other biologically active molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral building block in the synthesis of complex drug candidates, particularly those targeting neurological or cardiovascular systems.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of proprietary APIs where its specific stereochemistry and functional groups are essential for biological activity.
• Biochemical Research: Employed in academic and industrial research laboratories as a reference standard or a precursor for studying receptor-ligand interactions and structure-activity relationships (SAR).
• Process Chemistry Development: Utilized in the development and scale-up of synthetic routes for new chemical entities (NCEs) under Good Manufacturing Practice (GMP) conditions.
• Asymmetric Synthesis Catalyst/Precursor: Potential use as a precursor for chiral ligands or catalysts used in enantioselective transformations.

Basic Information

Product Name	(S)-5,6,7,8-Tetrahydro-6-[Propyl[2-(2-Thienyl)Ethyl]Amino]- 1-Naphthalenol Hydrogen Sulfate (Ester)
CAS No.	128478-69-3
Molecular Formula	C19H27NO4S2
Molecular Weight	397.55 g/mol
Synonyms	(S)-6-(N-Propyl-N-(2-(2-thienyl)ethyl)amino)-5,6,7,8-tetrahydro-1-naphthalenol hydrogen sulfate; (S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenol sulfate; (S)-6-[Propyl(2-thiophen-2-ylethyl)amino]-5,6,7,8-tetrahydro-1-naphthalenyl sulfate; (S)-6-(N-Propyl-N-(2-(thiophen-2-yl)ethyl)amino)-1,2,3,4-tetrahydro-1-naphthyl hydrogen sulfate; (S)-6-(Propyl(2-(thiophen-2-yl)ethyl)amino)-1,2,3,4-tetrahydro-1-naphthyl sulfate; (S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthol sulfate ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols. Every batch is characterized and tested to ensure high chiral purity and chemical integrity, with specifications tailored to meet the demanding requirements of pharmaceutical development. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for identity, assay, chiral purity, and impurity profiles. We support development under GMP guidelines for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.