Description

(S)-5,6,7,8-Tetrahydro-6-[Propyl[2-(2-Thienyl)Ethyl]Amino]-1-Naphthalenyl β-D-Glucopyranosiduronic Acid CAS NO 128464-29-9 is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and complex molecular structure. This compound is of significant value in the research and development of novel therapeutic agents, particularly those targeting the central nervous system. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of proprietary drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for neurological and psychiatric research.
• Metabolite Reference Standard: Used as an analytical standard in pharmacokinetic and drug metabolism studies for related parent compounds.
• Medicinal Chemistry Research: Serves as a crucial scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Biochemical Research: Employed in studies investigating enzyme interactions and receptor binding assays due to its specific glucuronide conjugate structure.
• Process Development: Utilized in the development and optimization of scalable synthetic routes for complex chiral molecules.

Basic Information

Product Name	(S)-5,6,7,8-Tetrahydro-6-[Propyl[2-(2-Thienyl)Ethyl]Amino]-1-Naphthalenyl β-D-Glucopyranosiduronic Acid
CAS No.	128464-29-9
Molecular Formula	C₂₅H₃₃NO₇S
Molecular Weight	491.60 g/mol
Synonyms	(S)-5,6,7,8-Tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-1-naphthalenyl β-D-glucopyranosiduronic acid; 6-[(2-(2-Thienyl)ethyl)propylamino]-5,6,7,8-tetrahydro-1-naphthyl β-D-glucopyranosiduronic acid (S-isomer); (S)-Zolmitriptan Glucuronide; Zolmitriptan N-Glucuronide (S-isomer); Zolmitriptan Metabolite M9; (S)-Zolmitriptan β-D-Glucuronide; (S)-6-[(2-(2-Thienyl)ethyl)propylamino]-5,6,7,8-tetrahydro-1-naphthyl β-D-glucuronide; 128464-29-9
EINECS	Contact for details

Quality Control

This high-value intermediate is produced under strict quality control protocols to ensure batch-to-batch consistency and purity suitable for research and development. Our quality system includes comprehensive analytical characterization using HPLC, NMR, and MS to confirm identity and purity. Certificates of Analysis (COA) detailing assay, chiral purity, and impurity profiles are provided with each shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (S-isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.