Description

(R)-4-Boc-Thiomorpholine-3-Carboxylic Acid is a high-purity chiral building block of significant importance in modern pharmaceutical research and development. This compound serves as a critical intermediate for the synthesis of complex molecules, particularly in the creation of novel active pharmaceutical ingredients (APIs) and drug candidates. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, especially those targeting neurological and metabolic disorders.
• Peptidomimetic Chemistry: Used to incorporate constrained, sulfur-containing heterocycles into peptide backbones to enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands used in asymmetric synthesis and catalysis.
• Chemical Biology Probes: Employed in the development of tool compounds and probes for studying biological pathways and protein function.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis projects for clients.
• Academic Research: Utilized in university and institutional labs for methodological development and exploration of new chemical space.

Basic Information

Product Name	(R)-4-Boc-Thiomorpholine-3-Carboxylic Acid
CAS No.	128453-98-5
Molecular Formula	C10H17NO4S
Molecular Weight	247.31 g/mol
Synonyms	(3R)-1,1-Dimethylethyl tetrahydro-4-oxo-2H-1,4-thiazine-3-carboxylate 1,1-Dimethylethyl ester; (R)-tert-Butyl 3-carboxytetrahydro-2H-1,4-thiazine-4(3H)-carboxylate; (R)-4-(tert-Butoxycarbonyl)thiomorpholine-3-carboxylic acid; Boc-Thiomorpholine-3-COOH (R-isomer); (R)-Boc-3-Thiomorpholinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our (R)-4-Boc-Thiomorpholine-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity, to meet the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.