Description

(S)-(-)-2-(Boc-Amino)-1,4-Butanediol CAS NO 128427-10-1 is a high-purity, chiral building block featuring a Boc-protected amino group and a terminal diol functionality. This compound is critically important for the synthesis of complex, optically active molecules, particularly in pharmaceutical research and development. It serves as a versatile intermediate for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), peptide mimetics, and other bioactive compounds. The defined stereochemistry and orthogonal protecting groups make it an essential reagent for constructing sophisticated molecular architectures with high precision.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially for oncology, antiviral, and central nervous system (CNS) drugs.
• Peptidomimetic Chemistry: Used to incorporate non-natural amino acid backbones and linkers into peptide-based drug candidates to enhance metabolic stability and bioavailability.
• Linker for Bioconjugation: The diol group enables its use as a spacer or linker in antibody-drug conjugates (ADCs) and other targeted therapeutic platforms.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective catalytic reactions to introduce specific stereocenters.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for creating functionalized, biodegradable polymers with specific chemical handles.
• Chemical Biology Probes: Utilized in the development of molecular probes and tools for studying biological pathways and target engagement.

Basic Information

Product Name	(S)-(-)-2-(Boc-Amino)-1,4-Butanediol
CAS No.	128427-10-1
Molecular Formula	C9H19NO4
Molecular Weight	205.25 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-1,4-butanediol; (S)-N-Boc-2-Amino-1,4-butanediol; (S)-2-(Boc-Amino)butane-1,4-diol; (S)-2-Amino-1,4-butanediol N-Boc derivative; tert-Butyl ((3S)-3,6-dihydroxy-1-butyl)carbamate; Boc-Abu-ol; (S)-BocNH-CH(CH2OH)CH2CH2OH
EINECS	Contact for details

Quality Control

Our (S)-(-)-2-(Boc-Amino)-1,4-Butanediol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) detailing identity, purity (by HPLC), chiral excess, and impurity profiles are provided with every shipment. We support compliance with global regulatory frameworks, including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.