Description

Fmoc-Val-Aib-Oh CAS NO 128422-18-4 is a protected dipeptide building block featuring the non-proteinogenic amino acid 2-aminoisobutyric acid (Aib). This compound is essential for the solid-phase peptide synthesis (SPPS) of peptides containing Aib residues, which are known to induce helical conformations and enhance metabolic stability. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptide therapeutics, peptidomimetics, and bioactive probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential assembly of complex peptides on resin.
• Peptidomimetic Drug Discovery: Incorporation of Aib to create stable, helix-inducing scaffolds that mimic natural peptides.
• Antimicrobial Peptide (AMP) Research: Used to synthesize analogs with improved protease resistance and biological activity.
• Bioconjugation and Labeling: Serves as a component in the synthesis of peptide-based imaging agents or drug conjugates.
• Structure-Activity Relationship (SAR) Studies: Enables systematic modification of peptide backbones to study the impact of conformational restraint.
• Academic and Industrial R&D: Fundamental research tool in organic chemistry, medicinal chemistry, and biochemistry laboratories.

Basic Information

Product Name	Fmoc-Val-Aib-Oh
CAS No.	128422-18-4
Molecular Formula	C25H30N2O5
Molecular Weight	438.52 g/mol
Synonyms	Fmoc-Val-Aib-OH; Fmoc-L-Valyl-2-aminoisobutyric acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-valyl-2-aminoisobutyric acid; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanoic acid-2-aminoisobutyric acid; Fmoc-Val-Aib; Fmoc-Val-Aib-OH (protected dipeptide); Fmoc-L-Val-Aib-OH; Nα-Fmoc-L-valyl-2-aminoisobutyric acid
EINECS	Contact for details

Quality Control

Our Fmoc-Val-Aib-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment, to ensure it meets the high standards required for peptide synthesis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral integrity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98.0%
Assay (Titration)	≥ 97.0%
Optical Rotation	-15.0° to -25.0° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.