Description

(-)-(R)-5-(2-((2-(o-Ethoxyphenoxy)Ethyl)Amino)Propyl)-2-Methoxybenzene Sulfonamide Monohydrochloride is a high-purity, single-enantiomer chiral compound of significant interest in advanced pharmaceutical research and development. This molecule serves as a critical intermediate or active pharmaceutical ingredient (API) for the synthesis of novel therapeutic agents, particularly those targeting adrenergic and cardiovascular pathways. It is essential for pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in the development of enantiomerically pure drugs, where its defined stereochemistry ensures precise biological activity and regulatory compliance.

Application

• Pharmaceutical Intermediate: A key chiral building block for the synthesis of enantiomerically pure β-adrenergic receptor antagonists (β-blockers).
• Active Pharmaceutical Ingredient (API) Development: Used in R&D for novel cardiovascular and central nervous system (CNS) drug candidates.
• Biochemical Research: Serves as a reference standard or ligand in receptor binding studies and pharmacological assays.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for commercial-scale API manufacturing.
• Asymmetric Synthesis: Utilized as a starting material or template in stereoselective synthesis protocols.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific drug development projects.

Basic Information

Product Name	(-)-(R)-5-(2-((2-(o-Ethoxyphenoxy)Ethyl)Amino)Propyl)-2-Methoxybenzene Sulfonamide Monohydrochloride
CAS No.	128332-25-2
Molecular Formula	C22H32N2O5S • HCl
Molecular Weight	489.02 g/mol
Synonyms	(R)-Carvedilol Impurity; (R)-Carvedilol Related Compound; (-)-Carvedilol Enantiomer; (R)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol Hydrochloride (related); 5-(2-((2-(2-Ethoxyphenoxy)ethyl)amino)propyl)-2-methoxybenzenesulfonamide, (R)-, monohydrochloride; UNII-6A0P8SJ17I; (R)-BM 14190; BM-14190 (R-enantiomer)
EINECS	Contact for details

Quality Control

Our (-)-(R)-5-(2-((2-(o-Ethoxyphenoxy)Ethyl)Amino)Propyl)-2-Methoxybenzene Sulfonamide Monohydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to support regulatory filings (e.g., ICH Q3A/B, FDA/EMEA guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-enantiomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.