Description

4-tert-Butyl-2-Iodo-Aniline is a halogenated aniline derivative that serves as a versatile and valuable building block in advanced organic synthesis. This compound is particularly significant for introducing both steric bulk and a reactive iodine handle into target molecules, enabling complex coupling reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those requiring iodinated aromatic cores for further functionalization via cross-coupling reactions like Suzuki or Sonogashira.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides where the tert-butyl and iodine substituents contribute to specific biological activity and metabolic stability.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and advanced polymers, where its molecular structure can influence electronic properties and self-assembly.
• Chemical Biology & Proteomics: Acts as a reagent for bioconjugation and labeling studies, leveraging the reactivity of the iodine atom for selective attachment to biomolecules.
• Catalyst Ligand Precursor: Serves as a starting material for synthesizing specialized nitrogen-containing ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical companies for use in bespoke, multi-step synthetic routes for client-specific targets.

Basic Information

Product Name	4-tert-Butyl-2-Iodo-Aniline
CAS No.	128318-63-8
Molecular Formula	C10H14IN
Molecular Weight	275.13 g/mol
Synonyms	2-Iodo-4-tert-butylaniline; 4-(1,1-Dimethylethyl)-2-iodobenzenamine; 4-tert-Butyl-2-iodoaniline; 2-Iodo-4-(tert-butyl)aniline; Benzenamine, 4-(1,1-dimethylethyl)-2-iodo-; p-tert-Butyl-o-iodoaniline
EINECS	Contact for details

Quality Control

Our 4-tert-Butyl-2-Iodo-Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and reliability for your critical syntheses.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	Light yellow to brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.