Description

Cyclopropanecarboxylic Acid, 2-Fluoro-1-Methyl-, Ethyl Ester, cis- (9Ci) is a high-purity, fluorinated cyclopropane derivative serving as a critical chiral building block in advanced organic synthesis. This compound matters for its unique structural motif, which is essential for modulating the biological activity and physicochemical properties of target molecules. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers developing novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly in central nervous system (CNS) and antiviral drug candidates.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the fluorinated cyclopropane ring enhances compound stability and efficacy.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of specialty polymers and liquid crystals with tailored properties.
• Chemical Biology Probes: Utilized as a building block for fluorinated probes and tags in mechanistic and diagnostic studies.
• Process Chemistry & Scale-up: Supports route scouting and optimization for the commercial manufacturing of complex molecules.

Basic Information

Product Name	Cyclopropanecarboxylic Acid, 2-Fluoro-1-Methyl-, Ethyl Ester, cis- (9Ci)
CAS No.	128230-91-1
Molecular Formula	C7H11FO2
Molecular Weight	146.16 g/mol
Synonyms	cis-Ethyl 2-Fluoro-1-methylcyclopropanecarboxylate; Ethyl cis-2-Fluoro-1-methylcyclopropanecarboxylate; 2-Fluoro-1-methylcyclopropanecarboxylic Acid Ethyl Ester, cis-; (1R,2S)- and (1S,2R)-Ethyl 2-Fluoro-1-methylcyclopropanecarboxylate; Fluoromethylcyclopropane carboxylate ethyl ester; Fluorinated Cyclopropane Ester; Chiral Fluorocyclopropane Building Block
EINECS	Contact for details

Quality Control

Our Cyclopropanecarboxylic Acid, 2-Fluoro-1-Methyl-, Ethyl Ester, cis- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment by HPLC, to ensure compliance with exacting customer and research standards. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are sealed under an inert atmosphere after opening to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.