Description

2,2-Difluoro-1-Methylcyclopropanamine Hydrochloride is a high-value, organofluorine building block essential for advanced chemical synthesis. Its unique difluorocyclopropane amine structure makes it a critical intermediate for introducing conformational rigidity and fluorine atoms into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, particularly in protease inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the difluorocyclopropane moiety can improve activity and environmental profile.
• Material Science Research: Serves as a precursor for specialty polymers and advanced materials requiring fluorinated components.
• Medicinal Chemistry: A versatile building block for constructing compound libraries in drug discovery programs focused on structure-activity relationship (SAR) studies.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and probes for studying biological mechanisms and enzyme interactions.

Basic Information

Product Name	2,2-Difluoro-1-Methylcyclopropanamine Hydrochloride
CAS No.	128230-76-2
Molecular Formula	C4H8ClF2N
Molecular Weight	143.56 g/mol
Synonyms	1-Methyl-2,2-difluorocyclopropanamine hydrochloride; 2,2-Difluoro-1-methylcyclopropan-1-amine hydrochloride; 1-Amino-2,2-difluoro-1-methylcyclopropane hydrochloride; α,α-Difluoro-β-methylcyclopropylamine hydrochloride; (1-Methyl-2,2-difluorocyclopropyl)amine hydrochloride; 2,2-Difluoro-1-methylcyclopropylamine HCl; 128230-76-2; 2,2-Difluoro-N-methylcyclopropanamine hydrochloride
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-1-Methylcyclopropanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process development. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.