Description

3-Amino-2-Hydroxy-4-Phenylbutyric Acid Hydrochloride is a chiral amino acid derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its role as a key intermediate for the production of pharmaceutical active ingredients, particularly protease inhibitors. This compound is essential for research and manufacturing organizations in the pharmaceutical, biotechnology, and fine chemical sectors seeking high-purity intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of HIV protease inhibitors and other antiviral drugs.
• Peptide Synthesis: Used as a non-proteinogenic amino acid building block for constructing specialized peptides with modified backbones.
• Medicinal Chemistry Research: Serves as a versatile scaffold for drug discovery programs targeting enzymatic pathways.
• Asymmetric Synthesis: Employed as a chiral auxiliary or precursor in stereoselective chemical transformations.
• Biochemical Research: Used in studies of enzyme inhibition and substrate specificity due to its structural similarity to natural amino acids.
• Fine Chemical Production: An intermediate for the manufacture of other high-value, specialized chemicals and ligands.

Basic Information

Product Name	3-Amino-2-Hydroxy-4-Phenylbutyric Acid Hydrochloride
CAS No.	128223-56-3
Molecular Formula	C10H14ClNO3
Molecular Weight	231.68 g/mol
Synonyms	AHPA-HCl; (2S,3S)-3-Amino-2-hydroxy-4-phenylbutyric acid hydrochloride; 3-Amino-2-hydroxy-4-phenylbutanoic acid hydrochloride; Statine derivative hydrochloride; (2S,3S)-AHPA-HCl; 3-Amino-2-hydroxy-4-phenylbutyrate HCl; NSC 339484 (Hydrochloride); L-Statine derivative hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Amino-2-Hydroxy-4-Phenylbutyric Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.