Description

(2S,3R)-3-Amino-2-Hydroxy-4-Phenylbutyric Acid Hydrochloride is a high-purity chiral amino acid derivative, serving as a critical building block in the synthesis of complex pharmaceutical compounds. Its defined stereochemistry is essential for creating biologically active molecules with high specificity and efficacy. This intermediate is primarily required by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of protease inhibitors and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of HIV protease inhibitors and other antiviral drugs.
• Peptide Synthesis: Used as a constrained, stereochemically defined amino acid component in the preparation of novel peptide analogs.
• Medicinal Chemistry Research: Serves as a crucial building block for structure-activity relationship (SAR) studies and the development of new active pharmaceutical ingredients (APIs).
• Bioconjugation: Utilized in the design of targeted drug delivery systems and diagnostic agents due to its functional groups.
• Chemical Biology: Acts as a probe or inhibitor in enzymatic studies, particularly those involving aspartyl proteases.

Basic Information

Item	Details
Product Name	(2S,3R)-3-Amino-2-Hydroxy-4-Phenylbutyric Acid Hydrochloride
CAS No.	128223-55-2
Molecular Formula	C10H14ClNO3
Molecular Weight	231.68 g/mol
Synonyms	(2S,3R)-AHPA-HCl; (2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoic acid hydrochloride; (2S,3R)-AHPBA-HCl; (3R)-3-Amino-(2S)-hydroxy-4-phenylbutyric acid hydrochloride; (2S,3R)-3-Amino-2-hydroxy-4-phenylbutyrate hydrochloride; NSC 339484; L-AHPBA hydrochloride (stereospecific)
EINECS	Contact for details

Quality Control

Our (2S,3R)-3-Amino-2-Hydroxy-4-Phenylbutyric Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP intermediate applications. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (2S,3R) isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.