Description

8-Chloro-2,3,4,5-tetrahydro-5-phenyl-1H-3-benzazepin-7-ol, hydrochloride, (R) is a high-purity chiral benzazepine derivative, a key intermediate in advanced pharmaceutical synthesis. Its primary value lies in its role as a critical building block for the development of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly those requiring enantiomerically pure intermediates for preclinical and clinical studies.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel dopamine receptor ligands and other CNS-active compounds.
• Research & Development: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.
• Process Chemistry: Serves as a validated starting material or intermediate in the scale-up and manufacturing of candidate drugs.
• Reference Standard: Employed as a high-purity analytical standard for method development and quality control in API production.
• Asymmetric Synthesis: Utilized in the development of enantioselective synthetic routes due to its defined (R) configuration.

Basic Information

Product Name	8-Chloro-2,3,4,5-tetrahydro-5-phenyl-1H-3-benzazepin-7-ol, hydrochloride, (R)
CAS No.	128145-75-5
Molecular Formula	C16H17Cl2NO
Molecular Weight	310.22 g/mol
Synonyms	(R)-8-Chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-ol hydrochloride; (R)-8-Chloro-2,3,4,5-tetrahydro-5-phenyl-1H-3-benzazepin-7-ol HCl; (R)-8-Chloro-5-phenyl-1,2,4,5-tetrahydro-3H-3-benzazepin-7-ol hydrochloride; (R)-8-Chloro-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol hydrochloride; (R)-8-Chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7-ol hydrochloride; (R)-SKF-38393 Hydrochloride (related derivative); (R)-8-Chloro-7-hydroxy-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
EINECS	Contact for details

Quality Control

Our 8-Chloro-2,3,4,5-tetrahydro-5-phenyl-1H-3-benzazepin-7-ol, hydrochloride, (R) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with stringent pharmaceutical-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R)-enantiomer
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.