Description

Boc-β-Homoaspartic Acid(Otbu) is a high-purity, protected amino acid derivative essential for advanced peptide synthesis and medicinal chemistry research. This compound provides critical orthogonality in solid-phase and solution-phase synthesis, enabling the precise construction of complex peptide architectures and peptidomimetics. It is a vital building block for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical sectors who require reliable, high-quality intermediates for drug discovery and development programs.

Application

• Peptide Synthesis: A key protected intermediate for the incorporation of β-homoaspartic acid residues into peptide chains, expanding structural diversity.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of novel therapeutic agents, including enzyme inhibitors and receptor modulators.
• Bioconjugation & Protein Engineering: Serves as a specialized linker or spacer molecule for modifying biomolecules and creating antibody-drug conjugates (ADCs).
• Combinatorial Chemistry: A valuable building block in libraries for high-throughput screening to identify new bioactive compounds.
• Agrochemical Research: Employed in the synthesis of novel peptides and amino acid analogs with potential pesticidal or growth-regulating activity.
• Academic & Institutional Research: Supports fundamental studies in organic synthesis, peptide science, and chemical biology.

Basic Information

Product Name	Boc-β-Homoaspartic Acid(Otbu)
CAS No.	128135-39-7
Molecular Formula	C14H25NO6
Molecular Weight	303.35 g/mol
Synonyms	(2S)-2-{[(tert-Butoxy)carbonyl]amino}pentanedioic acid 5-tert-butyl ester; N-Boc-β-homo-L-aspartic acid 5-tert-butyl ester; N-(tert-Butoxycarbonyl)-β-homo-L-aspartic acid 5-tert-butyl ester; Boc-β-homo-Asp(OtBu)-OH; Boc-L-β-homoaspartic acid(OtBu); tert-Butyl N-[(1S)-4-(tert-butoxy)-1,4-dioxobutan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our Boc-β-Homoaspartic Acid(Otbu) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and chiral integrity. Certificates of Analysis (COA) with detailed specifications are provided to guarantee batch-to-batch consistency and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.