Description

Benzyl 3-Hydroxyazetidine-1-Carboxylate is a high-purity, protected azetidine derivative serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile, functionalized scaffold for constructing complex molecules with precise stereochemistry. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, anti-infectives, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the azetidine ring can contribute to biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis to control stereoselectivity.
• Peptidomimetics and Bioisosteres: The 3-hydroxyazetidine moiety is a valuable bioisostere for other heterocycles or amino acids in designing peptide analogs with improved metabolic stability and potency.
• Chemical Biology Probes: Utilized in the synthesis of tool compounds and molecular probes for studying biological pathways and target engagement.
• Custom Synthesis and Contract Manufacturing: A fundamental starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences sector.

Basic Information

Product Name	Benzyl 3-Hydroxyazetidine-1-Carboxylate
CAS No.	128117-22-6
Molecular Formula	C11H13NO3
Molecular Weight	207.23 g/mol
Synonyms	1-[(Benzyloxy)carbonyl]-3-hydroxyazetidine; 3-Hydroxyazetidine-1-carboxylic Acid Benzyl Ester; 1-CBZ-3-Hydroxyazetidine; N-CBZ-3-Hydroxyazetidine; Azetidin-3-ol, 1-[(phenylmethoxy)carbonyl]-; Benzyl 3-hydroxy-1-azetidinecarboxylate; (3-Hydroxyazetidin-1-yl)(phenyl)methanone Benzyl Ester; 1-(Benzyloxycarbonyl)azetidin-3-ol
EINECS	Contact for details

Quality Control

Our Benzyl 3-Hydroxyazetidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.