Description

L-Prolinamide, n-((Hexahydro-1-Methyl-2,6-Dioxo-4-Pyrimidinyl)Carbonyl )-L-Histidyl-, (R)-, Hydrate is a high-purity, non-natural peptide derivative of significant interest in advanced pharmaceutical research and development. This compound is valued for its specific stereochemistry and structural complexity, which makes it a critical building block for creating novel bioactive molecules. It is primarily sought by research institutions and pharmaceutical companies engaged in the discovery and synthesis of new therapeutic agents, particularly in areas requiring sophisticated peptide chemistry.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug candidates, especially protease inhibitors and other targeted therapies.
• Peptide-Based Drug Discovery: Used as a specialized amino acid derivative for constructing novel peptide sequences with enhanced stability or biological activity.
• Biochemical Research: Employed as a reference standard or a tool compound in enzymatic studies and receptor-ligand interaction assays.
• Chemical Biology Probes: Incorporated into the design of molecular probes for studying specific biological pathways and protein functions.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for fundamental and applied research in medicinal chemistry.

Basic Information

Product Name	L-Prolinamide, n-((Hexahydro-1-Methyl-2,6-Dioxo-4-Pyrimidinyl)Carbonyl )-L-Histidyl-, (R)-, Hydrate
CAS No.	128111-67-1
Molecular Formula	C21H31N7O6 • xH2O
Molecular Weight	477.52 g/mol (Anhydrous basis)
Synonyms	(R)-L-Prolinamide, N-((Hexahydro-1-Methyl-2,6-Dioxo-4-Pyrimidinyl)Carbonyl)-L-Histidyl-, Hydrate; Histidyl-Prolinamide Derivative; NSC 339313; 1-Methyl-2,6-dioxo-4-piperidinecarboxylic acid, N-[N-[(2S)-2-amino-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl]-L-histidyl]-, (R)-, hydrate; A Peptide Mimetic; Ureidopeptide Derivative; Hydrated Peptidomimetic
EINECS	Contact for details

Quality Control

Every batch of this advanced chemical intermediate is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles, ensuring traceability and consistency for your critical research and development work. Our quality systems are designed to support cGMP compliance for pharmaceutical applications, with documentation available for audit purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.