Description

(1R,2S)-(-)-2-Amino-1-Cyclopentanecarboxylic Acid Hydrochloride is a high-purity, non-proteinogenic amino acid derivative, specifically the hydrochloride salt of the cis-2-aminocyclopentanecarboxylic acid enantiomer. This compound is a critical chiral building block and intermediate in the synthesis of complex pharmaceutical molecules, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptidomimetics, enzyme inhibitors, and other bioactive compounds where the rigid cyclopentane scaffold is advantageous.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and neurological drug candidates.
• Peptidomimetics & Constrained Peptides: Used to introduce conformational rigidity into peptide backbones, enhancing metabolic stability and receptor selectivity in drug design.
• Enzyme Inhibitor Synthesis: Serves as a core structure in designing potent and selective inhibitors for proteases and other enzymes.
• Asymmetric Catalysis Ligand Precursor: Can be utilized in the preparation of chiral ligands for asymmetric synthesis.
• Biochemical Research: Employed in studies of amino acid transport, metabolism, and as a tool compound in neuropharmacology.
• Agrochemical Intermediates: Potential use in the synthesis of chiral, biologically active compounds for crop protection.

Basic Information

Item	Detail
Product Name	(1R,2S)-(-)-2-Amino-1-Cyclopentanecarboxylic Acid Hydrochloride
CAS No.	128110-37-2
Molecular Formula	C6H12ClNO2
Molecular Weight	165.62 g/mol
Synonyms	(1R,2S)-2-Aminocyclopentanecarboxylic acid hydrochloride; cis-2-Aminocyclopentanecarboxylic acid hydrochloride; (1R,2S)-ACPC HCl; (-)-cis-2-Aminocyclopentane-1-carboxylic acid hydrochloride; (1R,2S)-2-Amino-1-cyclopentanecarboxylic acid monohydrochloride; cis-2-Amino-1-cyclopentanecarboxylic acid HCl; (1R,2S)-ACPC-HCl
EINECS	Contact for details

Quality Control

Our (1R,2S)-(-)-2-Amino-1-Cyclopentanecarboxylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity, chiral integrity, and consistent performance. Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and residual solvent levels are provided with every shipment. We can support development projects with material meeting GMP-grade standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.